1. Department of Biomolecular Medicine, Faculty of Medicine, Imperial College London, South Kensington, London, SW7 2AZ, U.K., Department of Epidemiology & Public Health, Faculty of Medicine, Imperial College London, St Mary’s Campus, Norfolk Place, London, W2 1PG, U.K., Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, and School of Biological and Chemical Sciences, Queen Mary and Westfield College, University of London, Mile End Road, London E1 4NS, U.K.