Metabonomics: a platform for studying drug toxicity and gene function-Reference-Cited by-同舟云学术

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Metabonomics: a platform for studying drug toxicity and gene function

Published:2002-02 Issue:2 Volume:1 Page:153-161
ISSN:1474-1776
Container-title:Nature Reviews Drug Discovery
language:en
Short-container-title:Nat Rev Drug Discov

Author:

Nicholson Jeremy K.,Connelly John,Lindon John C.,Holmes Elaine

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Link

http://www.nature.com/articles/nrd728.pdf

Reference86 articles.

1. Nicholson, J. K., Lindon, J. C. & Holmes, E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data. Xenobiotica 29, 1181–1189 (1999).

2. Lindon, J. C., Nicholson, J. K., Holmes, E. & Everett, J. R. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn. Reson. 12, 289–320 (2000).

3. Holmes, E., Nicholson, J. K. & Tranter, G. Metabonomic classification of genetic variations in toxicological and metabolic responses using probabalistic neural networks. Chem. Res. Toxicol. 14, 182–191 (2001).

4. Robertson, D. G. et al. Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. Toxicol. Sci. 57, 326–337 (2000).

5. Gartland, K. P. R. et al. Pattern recognition analysis of high resolution 1H NMR spectra of urine: a nonlinear mapping approach to the classification of toxicological data. NMR Biomed. 3, 166–172 (1990).

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