Discovery of a Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitor for the Potential Treatment of Schizophrenia-Reference-Cited by-同舟云学术

Discovery of a Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitor for the Potential Treatment of Schizophrenia

Published:2014-05-09 Issue:10 Volume:57 Page:4196-4212
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bartolomé-Nebreda José Manuel¹²,Delgado Francisca¹²,Martín-Martín María Luz¹²,Martínez-Viturro Carlos M.¹²,Pastor Joaquín¹²,Tong Han Min¹²,Iturrino Laura¹²,Macdonald Gregor J.¹²,Sanderson Wendy¹²,Megens Anton¹²,Langlois Xavier¹²,Somers Marijke¹²,Vanhoof Greet¹²,Conde-Ceide Susana¹²

Affiliation:

1. Neuroscience Medicinal Chemistry and ‡Discovery Sciences Analytical Sciences, Janssen Research & Development, Calle Jarama 75, Polígono Industrial, Toledo 45007, Spain

2. Neuroscience Medicinal Chemistry, ∥Discovery Sciences Molecular Informatics, ⊥Neuroscience Biology, #Discovery Sciences ADME/Tox, and ∇Discovery Sciences Translational Sciences, Janssen Research & Development, Turnhoutseweg 30, B-2340, Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500073h

Reference44 articles.

1. Schizophrenia, “just the facts” 4. Clinical features and conceptualization

2. Targeting the dopamine D2receptor in schizophrenia

3. Treatment of schizophrenia and spectrum disorders: pharmacotherapy, psychosocial treatments, and neurotransmitter interactions

4. Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

5. A Decade of Progress in the Discovery and Development of ‘Atypical’ Antipsychotics

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