A New Insight into the Synthesis and Biological Activities of Pyrazole based Derivatives-Reference-Cited by-同舟云学术

A New Insight into the Synthesis and Biological Activities of Pyrazole based Derivatives

Published:2022-09 Issue:6 Volume:19 Page:717-778
ISSN:1570-193X
Container-title:Mini-Reviews in Organic Chemistry
language:en
Short-container-title:MROC

Author:

Mor Satbir¹,Khatri Mohini¹,Punia Ravinder¹,Nagoria Savita²,Sindhu Suchita¹

Affiliation:

1. Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana, India

2. Department of Chemistry, Government College, Hisar-125001, Haryana, India

Abstract

Abstract: The aim of this review is to collate literature work reported by researchers (from 1994 to 2021) to provide an overview of the available methodologies for the synthesis and diverse pharmacological activities exhibited by pyrazole based molecules. This review highlights recent reports on various routes of synthesis and potential biological evaluation studies viz. anticancer, AT (II) inhibitory, anti-inflammatory activities, HIV-1-RT inhibitory, antihypertensive, herbicidal, antitubercular, insecticidal, antiviral, antimicrobial and COX-2 inhibitory activity, etc. of pyrazole derivatives and also presents recent efforts made on this heterocyclic moiety.

Funder

University Grants Commission, India

Council of Scientific & Industrial Research, New Delhi

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

Reference277 articles.

1. Eicher, T.; Hauptmann, S. The chemistry of heterocycles: Structures, reactions, syntheses, and applications, 2nd ed.; Wiley- VCH GmbH

2. Dhawan S.N.; Mor S.; Sharma K.; Chawla A.D.; Saini A.; Gupta S.C.; On the mechanism of formation of pyrazoles from 1,3-diketones and hydrazines: isolation of hydroxypyrazoline intermediates. Indian J Chem 1994,33B,38-42

3. Penning T.D.; Talley J.J.; Bertenshaw S.R.; Carter J.S.; Collins P.W.; Docter S.; Graneto M.J.; Lee L.F.; Malecha J.W.; Miyashiro J.M.; Rogers R.S.; Rogier D.J.; Yu S.S.; Anderson G.D.; Burton E.G.; Cogburn J.N.; Gregory S.A.; Koboldt C.M.; Perkins W.E.; Seibert K.; Veenhuizen A.W.; Zhang Y.Y.; Isakson P.C.; Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem 1997,40(9),1347-1365

4. Lan R.; Liu Q.; Fan P.; Lin S.; Fernando S.R.; McCallion D.; Pertwee R.; Makriyannis A.; Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem 1999,42(4),769-776

5. Varano F.; Catarzi D.; Colotta V.; Filacchioni G.; Galli A.; Costagli C.; Carlà V.; Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. J Med Chem 2002,45(5),1035-1044

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Molecular Investigations of Novel Pyrano[2,3-c]Pyrazole Congeners as Potential HCoV-229E Inhibitors: synthesis, Molecular Modeling, 3D QSAR, and ADMET Screening;Polycyclic Aromatic Compounds;2024-09-11

2. Facile synthesis and in silico studies of benzothiazole-linked hydroxypyrazolones targeting α -amylase and α -glucosidase;Future Medicinal Chemistry;2024-05-18

3. Synthesis, in silico ADMET prediction analysis, and pharmacological evaluation of sulfonamide derivatives tethered with pyrazole or pyridine as anti-diabetic and anti-Alzheimer's agents;Saudi Pharmaceutical Journal;2024-05

4. Design, synthesis, α-amylase and glucose diffusion inhibition, and molecular docking studies of new indenopyrazolones bearing benzothiazole derivatives;Bioorganic & Medicinal Chemistry Letters;2024-05

5. Discovery of Pyrano[2,3-c]pyrazole Derivatives as Novel Potential Human Coronavirus Inhibitors: Design, Synthesis, In Silico, In Vitro, and ADME Studies;Pharmaceuticals;2024-02-02