Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity-Reference-Cited by-同舟云学术

Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

Published:2006-12-01 Issue:26 Volume:49 Page:7584-7587
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lin Linus S.¹,Lanza, Thomas J.¹,Jewell James P.¹,Liu Ping¹,Shah Shrenik K.¹,Qi Hongbo¹,Tong Xinchun¹,Wang Junying¹,Xu Suoyu S.¹,Fong Tung M.¹,Shen Chun-Pyn¹,Lao Julie¹,Xiao Jing Chen¹,Shearman Lauren P.¹,Stribling D. Sloan¹,Rosko Kimberly¹,Strack Alison¹,Marsh Donald J.¹,Feng Yue¹,Kumar Sanjeev¹,Samuel Koppara¹,Yin Wenji¹,Van der Ploeg Lex H. T.¹,Goulet Mark T.¹,Hagmann William K.¹

Affiliation:

1. Departments of Medicinal Chemistry, Metabolic Disorders, Pharmacology, and Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060996%2B

Reference18 articles.

1. A Potential Decline in Life Expectancy in the United States in the 21st Century

2. Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development

Cited by 125 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pharmacological Evaluation of Cannabinoid Receptor Modulators Using GRABeCB2.0 Sensor;International Journal of Molecular Sciences;2024-05-03

2. Impact of Cannabinoid Receptors in the Design of Therapeutic Agents against Human Ailments;Current Topics in Medicinal Chemistry;2023-07

3. A colorimetric and fluorescent signaling probe for assaying Pd²⁺ in practical samples;RSC Advances;2023

4. Regioselective O-alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion;Chemical Communications;2023

5. Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones;Chemical Communications;2022