Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

Author:

Lu Zhiqiang12ORCID,Li Yanzhi12,Ru Yi1,Yang Shujian1,Hao Chu1,Zuo Mengke1,Jiao Rongkai1,Wu Weilong1,Zhou Yan1,Yao Hui2ORCID,Huang Nianyu2,Fu Yuqin1

Affiliation:

1. College of Chemistry and Chemical Engineering and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, 471934, P. R. China

2. Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, Yichang, China Three Gorges University, 443002, P. R. China

Abstract

A novel tactic for the regioselective O-alkylation of 2-pyridones has been realized through palladium catalysis facilitated by silver carbonate in moderate to high yields, the coordination effect between palladium and nitrogen on the pyridine ring plays a versatile role.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Henan Province

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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