Synthesis and Pharmacological Activities of 6-Glycine Substituted 14-Phenylpropoxymorphinans, a Novel Class of Opioids with High Opioid Receptor Affinities and Antinociceptive Potencies

Author:

Spetea Mariana1,Windisch Petra1,Guo Yan2,Bileviciute-Ljungar Indre2,Schütz Johannes1,Asim Muhammad Faheem1,Berzetei-Gurske Ilona P.3,Riba Pal4,Kiraly Kornel4,Fürst Susanna4,Al-Khrasani Mahmoud4,Schmidhammer Helmut1

Affiliation:

1. Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria

2. Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden

3. Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, United States

4. Department of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Nagyvarad ter 4, POB 370, H-1445 Budapest, Hungary

Funder

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference56 articles.

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2. Chronic Pain

3. Opioid Complications and Side Effects

4. McNally, G. P.; Akil, H.Opioid Peptides and Their Receptors: Overview and Function in Pain Modulation. InNeuropsychopharmacology: The Fifth Generation of Progress;Davis, K. L.; Charney, D.; Coyle, J. T.; Nemeroff, C., Eds.Lippincott Williams & Wilkins:Philadelphia, 2002; pp34−46.

5. Opioid receptors: From binding sites to visible molecules in vivo

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