A Large-Scale Synthesis of Potent Glucokinase Activator MK-0941 via Selective O-Arylation and O-Alkylation
Author:
Affiliation:
1. Department of Process Research, Merck Research Laboratories, Rahway, New Jersey 07065, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op200068c
Reference23 articles.
1. Molecular Physiology of Mammalian Glucokinase
2. Hypothesis: Structures, evolution, and ancestor of glucose kinases in the hexokinase family
3. Assessing the potential of glucokinase activators in diabetes therapy
4. Medicinal Chemistry Approaches for Glucokinase Activation to Treat Type 2 Diabetes
5. Iino, T.; Hashimoto, N.; Nakajima, H.; Takahashi, K.; Nishimura, T.; Eiki, J.PCT Int. Appl. WO/2004/076420, 2004, CAN 141:260754.
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4. Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus;European Journal of Medicinal Chemistry;2018-08
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