Assessing the potential of glucokinase activators in diabetes therapy

Author:

Matschinsky Franz M.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Reference145 articles.

1. Matschinsky, F. M. et al. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes 55, 1–12 (2006).

2. Grimsby, J. et al. Allosteric activation of islet and hepatic glucokinase: a potential new approach to diabetes therapy. Diabetes Abstr. 50 (Suppl. 2), A115 (2001).

3. Doliba, N. et al. Novel pharmacological glucokinase activators enhance glucose metabolism, respiration and insulin release in isolated pancreatic islets demonstrating a unique therapeutic potential (Abstr. 1495-P; 61st ADA Meeting, Philadelphia). Diabetes 50 (Suppl. 2), A359 (2001).

4. Cuesta-Munoz, A. L. et al. Novel pharmacological glucokinase activators partly or fully reverse the catalytic defects of inactivating glucokinase missense mutants that cause MODY-2. Diabetes Abstr. 50 (Suppl. 2), A109 (2001).

5. Grimsby, J. et al. Allosteric activators of glucokinase: potential role in diabetes therapy. Science 301, 370–373 (2003). First peer-reviewed report on the discovery and potential of GKAs.

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