Ab Initio QM/MM Study Shows There Is No General Acid in the Reaction Catalyzed by 4-Oxalocrotonate Tautomerase-Reference-Cited by-同舟云学术

Ab Initio QM/MM Study Shows There Is No General Acid in the Reaction Catalyzed by 4-Oxalocrotonate Tautomerase

Published:2003-08-01 Issue:34 Volume:125 Page:10384-10393
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Cisneros G. Andrés¹,Liu Haiyan¹,Zhang Yingkai¹,Yang Weitao¹

Affiliation:

1. Contribution from the Department of Chemistry, Duke University, Box 90346, Durham, North Carolina 27708-0346, School of Life Science, University of Science and Technology of China, Hefei, Anhui, 230026, China, and Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, 9500 Gillman Drive, La Jolla, California 92093-0365

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja029672a

Reference31 articles.

1. 4-Oxalocrotonate tautomerase, an enzyme composed of 62 amino acid residues per monomer.

2. Physically associated enzymes produce and metabolize 2-hydroxy-2,4-dienoate, a chemically unstable intermediate formed in catechol metabolism via meta cleavage in Pseudomonas putida

3. 4-Oxalocrotonate tautomerase, a 41-kDa homohexamer: Backbone and side-chain resonance assignments, solution secondary structure, and location of active site residues by heteronuclear NMR spectroscopy

4. Crystal Structure of 4-Oxalocrotonate Tautomerase Inactivated by 2-Oxo-3-pentynoate at 2.4 Å Resolution: Analysis and Implications for the Mechanism of Inactivation and Catalysis,

5. Ketonization of 2-hydroxy-2,4-pentadienoate by 4-oxalocrotonate tautomerase: implications for the stereochemical course and the mechanism

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