Insight into wild-type and T1372E TET2-mediated 5hmC oxidation using ab initio QM/MM calculations
Author:
Affiliation:
1. Department of Chemistry
2. Wayne State University
3. Detroit
4. USA
5. University of North Texas
6. Denton
Abstract
T1372E TET2 stalls at 5hmC due to unfavorable orientation of substrate, which increases barrier of the rate limiting step.
Funder
Foundation for the National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC02961J
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