Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region-Reference-Cited by-同舟云学术

Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

Published:2014-06-03 Issue:11 Volume:57 Page:4584-4597
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kawatkar Sameer P.¹,Keating Thomas A.¹,Olivier Nelson B.¹,Breen John N.¹,Green Oluyinka M.¹,Guler Satenig Y.¹,Hentemann Martin F.¹,Loch James T.¹,McKenzie Andrew R.¹,Newman Joseph V.¹,Otterson Linda G.¹,Martínez-Botella Gabriel¹

Affiliation:

1. Infection Innovative Medicines and ‡Discovery Sciences, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500463c

Reference29 articles.

1. Antibiotics for Emerging Pathogens

2. Drugs for bad bugs: confronting the challenges of antibacterial discovery

3. Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation