Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region
Author:
Affiliation:
1. Infection Innovative Medicines and ‡Discovery Sciences, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm500463c
Reference29 articles.
1. Antibiotics for Emerging Pathogens
2. Drugs for bad bugs: confronting the challenges of antibacterial discovery
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4. In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound
5. Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
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