A Physiologically Based Modeling Strategy during Preclinical CNS Drug Development-Reference-Cited by-同舟云学术

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A Physiologically Based Modeling Strategy during Preclinical CNS Drug Development

Published:2014-01-29 Issue:3 Volume:11 Page:836-848
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Ball Kathryn¹,Bouzom François¹,Scherrmann Jean-Michel²³,Walther Bernard¹,Declèves Xavier²³

Affiliation:

1. Centre de Pharmacocinétique et Métabolisme, Groupe de Recherche Servier, Orléans, France

2. Neuropsychopharmacologie des addictions (CNRS UMR 8206), Faculté de Pharmacie, Université Paris Descartes, Paris, France

3. INSERM U705, Neuropsychopharmacologie des addictions, Paris, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp400533q

Reference38 articles.

1. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

2. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

3. Translational CNS medicines research

4. Physiologically Based Pharmacokinetic Modelling of Drug Penetration Across the Blood–Brain Barrier—Towards a Mechanistic IVIVE-Based Approach

5. Use of a Physiologically Based Pharmacokinetic Model to Study the Time to Reach Brain Equilibrium: An Experimental Analysis of the Role of Blood-Brain Barrier Permeability, Plasma Protein Binding, and Brain Tissue Binding

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