Derivation of Benzothiadiazine‐1,1‐dioxide Scaffolds via Transition Metal‐Catalyzed C—H Activation/Annulation

Abstract

Comprehensive SummaryBenzothiadiazine‐1,1‐dioxide scaffold is bioactive framework with wild utility and applications. Synthesis of benzothiadiazine‐fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal‐catalyzed C—H activation/annulation was reported. 3‐Phenyl‐2H‐benzothiadiazine‐1,1‐dioxide was used as the reaction substrate, and vinylene carbonate and 4‐diazopyrazolone were used as the coupling reagents, respectively. This strategy provides straightforward access to complex N‐heterocycles in a highly efficient and simple manner.