Toward Tissue-Selective Pancreatic B-Cells KATP Channel Openers Belonging to 3-Alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-Dioxides-Reference-Cited by-同舟云学术

Toward Tissue-Selective Pancreatic B-Cells KATP Channel Openers Belonging to 3-Alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-Dioxides

Published:2003-06-19 Issue:15 Volume:46 Page:3342-3353
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

de Tullio Pascal¹,Becker Bénédicte¹,Boverie Stéphane¹,Dabrowski Michael¹,Wahl Philip¹,Antoine Marie-Hélène¹,Somers Fabian¹,Sebille Sophie¹,Ouedraogo Raogo¹,Hansen John Bondo¹,Lebrun Philippe¹,Pirotte Bernard¹

Affiliation:

1. Centre de Recherche en Pharmacochimie des Substances Naturelles et Synthétiques, Laboratoire de Chimie Pharmaceutique, Université de Liège, 1, Avenue de l'Hôpital, CHU, Tour 4, B-4000 Liège, Belgium, University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, U.K., Laboratoire de Pharmacodynamie et de Thérapeutique, Université Libre de Bruxelles, 808, Route de Lennik, B-1070 Bruxelles, Belgium, and Discovery, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Malov, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm021117w

Reference36 articles.

1. The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

2. Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle

3. Adenosine 5'-Triphosphate-Sensitive Potassium Channels

4. Regulation of K+ channels plays a crucial role in the control of insulin secretion

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