Preparation of 8-Substituted Xanthine CVT-124 Precursor by Late Stage Pyrimidine Ring Closure-Reference-Cited by-同舟云学术

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Preparation of 8-Substituted Xanthine CVT-124 Precursor by Late Stage Pyrimidine Ring Closure

Published:2001-12-07 Issue:1 Volume:67 Page:188-193
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Herr R. Jason¹,Vogt Paul F.¹,Meckler Harold¹,Trova Michael P.¹,Schow Steven R.²,Petter Russell C.³

Affiliation:

1. Medicinal Chemistry and Chemical Development Departments, Albany Molecular Research, Inc., P.O. Box 15098, Albany, New York 12212-5098

2. Medicinal Chemistry Department, CV Therapeutics, 3172 Porter Drive, Palo Alto, California 94304

3. Medicinal Chemistry Department, Biogen, Inc., Fourteen Cambridge Center, Cambridge, Massachusetts 02142

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo015925r

Reference24 articles.

1. Convenient One-Pot Synthesis of 8-Substituted Xanthines from 6-Amino-5-Nitrosouracils

2. Synthesis and Biological Evaluation of the Enantiomers of the Potent and Selective A1-Adenosine Antagonist 1,3-Dipropyl-8-[2-(5,6-epoxynorbonyl)]- xanthine

3. 8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors

4. Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure

5. Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity

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1. Recent Developments towards the Synthesis of Pyrimidopyrimidine and Purine Derivatives;ChemistrySelect;2023-07-10

2. Xanthine Scaffold: Available Synthesis Routes to Deliver Diversity by Derivatization;Mini-Reviews in Organic Chemistry;2021-03-26

3. Copper-Catalyzed Intramolecular C–H Amination: A New Entry to Substituted Xanthine Derivatives;Synthesis;2017-05-09

4. Concise Xanthine Synthesis through a Double-Amidination Reaction of a 6-Chlorouracil with Amidines using Base-Metal Catalysis;ChemSusChem;2017-01-12

5. Pinner Reaction;Comprehensive Organic Name Reactions and Reagents;2010-09-15

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