3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors
Author:
Affiliation:
1. Global Discovery Chemistry/Oncology & Exploratory Chemistry, Novartis Institutes for Biomedical Research, 4560 Horton Street, Emeryville, California 94608, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml200029w
Reference26 articles.
1. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
2. Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development
3. Bipartite Binding of a Kinase Activator Activates Cdc7-related Kinase Essential for S Phase
4. Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex
5. Drf1, a novel regulatory subunit for human Cdc7 kinase
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