Development of a Practical and Scalable Synthesis of a Potent p38 Mitogen-Activated Protein Kinase Inhibitor-Reference-Cited by-同舟云学术

Development of a Practical and Scalable Synthesis of a Potent p38 Mitogen-Activated Protein Kinase Inhibitor

Published:2012-10-24 Issue:11 Volume:16 Page:1818-1826
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Yoshida Shinya¹,Hayashi Yasumasa¹,Obitsu Kazuyoshi¹,Nakamura Atsushi¹,Kikuchi Takashi¹,Sawada Tatsuya¹,Kimura Takenori²,Takahashi Takumi³,Mukuta Takashi¹

Affiliation:

1. Process Chemistry Laboratories, Astellas Pharma Inc., 160-2 Akahama, Takahagi-shi, Ibaraki 318-0001, Japan

2. Astellas Research Technologies Company, Ltd., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan

3. Supply Chain Management, Astellas Pharma Inc., 2-3-11, Nihonbashi-Honcho, Chuo-ku, Tokyo 103-8411, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op300237b

Reference17 articles.

1. Identification, Synthesis, and Biological Evaluation of 6-[(6R)-2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a Potent p38 MAP Kinase Inhibitor

2. Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer

3. Development of a Practical Synthesis of a Pyrazolopyridinone-Based p38 MAP Kinase Inhibitor

4. Development of a Practical and Scalable Synthesis of (R)- and (S)-3-Amino-2-[(benzyloxy)methyl]propan-1-ol Monohydrochloride: A Useful C-4 Chiral Building Block

5. Synthesis and serotonin transporter activity of sulphur-substituted α-alkyl phenethylamines as a new class of anticancer agents

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. LiHMDS, NaHMDS and KHMDS;Journal of Synthetic Organic Chemistry, Japan;2024-07-01

2. AgOTf-catalyzed reaction of sulfonyl hydrazones with ynamides led to stereoselective synthesis of α-amino alkenyl-substituted hydrazone derivatives;Tetrahedron;2019-09

3. A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: a mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates;Beilstein Journal of Organic Chemistry;2019-07-10

4. Efficient Azacycle Formations Developed in Japanese Pharmaceutical Industries: Elegancy, Logistics, and Training (ELT) “Sandwich” for Process Chemists;Organic Process Research & Development;2019-01-31

5. Selective S-methylation of highly fluorinated thiocarbamates;Synthetic Communications;2016-12-02