Development of a Practical Synthesis of a Pyrazolopyridinone-Based p38 MAP Kinase Inhibitor-Reference-Cited by-同舟云学术

Development of a Practical Synthesis of a Pyrazolopyridinone-Based p38 MAP Kinase Inhibitor

Published:2010-11-16 Issue:1 Volume:15 Page:31-43
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Milburn Robert R.¹,Thiel Oliver R.¹,Achmatowicz Michal¹,Wang Xiang¹,Zigterman Jamie¹,Bernard Charles¹,Colyer John T.¹,DiVirgilio Evan¹,Crockett Rich¹,Correll Tiffany L.¹,Nagapudi Karthik¹,Ranganathan Kumar¹,Hedley Simon J.¹,Allgeier Alan¹,Larsen Robert D.¹

Affiliation:

1. Amgen Inc., One Amgen Center Drive, Thousand Oaks, California, 91362, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op100205s

Reference45 articles.

1. MAP Kinases

2. Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

3. Protein Kinases as Small Molecule Inhibitor Targets in Inflammation