Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
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Published:2020-12-02
Issue:23
Volume:63
Page:14700-14723
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ISSN:0022-2623
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Container-title:Journal of Medicinal Chemistry
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language:en
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Short-container-title:J. Med. Chem.
Author:
Shukla Manojkumar R.1ORCID, Patra Sukanya1, Verma Mahip1, Sadasivam Gayathri1, Jana Nirmal1, Mahangare Sachin J.1, Vidhate Prashant1, Lagad Dipak1, Tarage Anand1, Cheemala Murthy1, Kulkarni Chaitanya1, Bhagwat Shankar1, Chaudhari Vinod D.1, Sayyed Majid1, Pachpute Vipul1, Phadtare Ramesh1, Gole Gopal1, Phukan Samiron1, Sunkara Brahmam1, Samant Charudatt1, Shingare Manisha1, Naik Aditya1, Trivedi Sneha1, Marisetti Ajit Kumar1, Reddy Madhusudhan1, Gholve Milind1, Mahajan Nilesh1, Sabde Sudeep1, Patil Vinod1, Modi Dipak1, Mehta Maneesh1, Nigade Prashant1, Tamane Kaustubh1, Tota Swati1, Goyal Hemant1, Volam Harish1, Pawar Shashikant1, Ahirrao Prajakta1, Dinchhana Lal1, Mallurwar Sadanand1, Akarte Atul1, Bokare Anand1, Kanhere Rupesh1, Reddy Neetinkumar1, Koul Sarita1, Dandekar Manoj1, Singh Minakshi1, Bernstein Peter R.1ORCID, Narasimham Lakshmi1, Bhonde Mandar1, Gundu Jayasagar1, Goel Rajan1, Kulkarni Sanjeev1, Sharma Sharad1, Kamboj Rajender Kumar1, Palle Venkata P.1
Affiliation:
1. Novel Drug Discovery and Development, Lupin Ltd., Lupin Research Park, Survey No. 46 A/47A, Village Nande, Taluka
Mulshi, Pune 412115, India
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Cited by
8 articles.
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