Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models

Author:

Shukla Manojkumar R.1ORCID,Patra Sukanya1,Verma Mahip1,Sadasivam Gayathri1,Jana Nirmal1,Mahangare Sachin J.1,Vidhate Prashant1,Lagad Dipak1,Tarage Anand1,Cheemala Murthy1,Kulkarni Chaitanya1,Bhagwat Shankar1,Chaudhari Vinod D.1,Sayyed Majid1,Pachpute Vipul1,Phadtare Ramesh1,Gole Gopal1,Phukan Samiron1,Sunkara Brahmam1,Samant Charudatt1,Shingare Manisha1,Naik Aditya1,Trivedi Sneha1,Marisetti Ajit Kumar1,Reddy Madhusudhan1,Gholve Milind1,Mahajan Nilesh1,Sabde Sudeep1,Patil Vinod1,Modi Dipak1,Mehta Maneesh1,Nigade Prashant1,Tamane Kaustubh1,Tota Swati1,Goyal Hemant1,Volam Harish1,Pawar Shashikant1,Ahirrao Prajakta1,Dinchhana Lal1,Mallurwar Sadanand1,Akarte Atul1,Bokare Anand1,Kanhere Rupesh1,Reddy Neetinkumar1,Koul Sarita1,Dandekar Manoj1,Singh Minakshi1,Bernstein Peter R.1ORCID,Narasimham Lakshmi1,Bhonde Mandar1,Gundu Jayasagar1,Goel Rajan1,Kulkarni Sanjeev1,Sharma Sharad1,Kamboj Rajender Kumar1,Palle Venkata P.1

Affiliation:

1. Novel Drug Discovery and Development, Lupin Ltd., Lupin Research Park, Survey No. 46 A/47A, Village Nande, Taluka Mulshi, Pune 412115, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3