Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling

Author:

Myklebust June H.123,Brody Joshua14,Kohrt Holbrook E.1,Kolstad Arne5,Czerwinski Debra K.1,Wälchli Sébastien236,Green Michael R.17,Trøen Gunhild8,Liestøl Knut39,Beiske Klaus8,Houot Roch1011,Delabie Jan12,Alizadeh Ash A.1,Irish Jonathan M.113,Levy Ronald1

Affiliation:

1. Oncology Division, Department of Medicine, Stanford University, Stanford, CA;

2. Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway;

3. Center for Cancer Biomedicine, University of Oslo, Oslo, Norway;

4. Lymphoma Immunotherapy Program, Mount Sinai School of Medicine, New York, NY;

5. Cancer Clinic, Department of Oncology, and

6. Department of Cellular Therapy, Oslo University Hospital, Oslo, Norway;

7. Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE;

8. Cancer Clinic, Department of Pathology, Oslo University Hospital, Oslo, Norway;

9. Department of Informatics, University of Oslo, Oslo, Norway;

10. Service d’Hématologie Clinique, Centre Hospitalier Universitaire de Rennes, Rennes, France;

11. INSERM U917, Université de Rennes, Rennes, France;

12. Laboratory Medicine and Pathology, University of Toronto, Toronto, ON, Canada; and

13. Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN

Abstract

Key Points Contrasting patterns of basal phosphorylation levels and α-BCR–induced signaling between CLL and MCL tumors. Direct association between BCR-induced signaling strength and CD79B level, but inverse association with BTK and SYK inhibitor efficacy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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