Development of a Practical and Scalable Synthesis of (R)- and (S)-3-Amino-2-[(benzyloxy)methyl]propan-1-ol Monohydrochloride: A Useful C-4 Chiral Building Block
Author:
Affiliation:
1. Astellas Research Technologies Co., Ltd., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op3001383
Reference38 articles.
1. Chemoenzymic preparation of asymmetrized tris(hydroxymethyl)methane (THYM*) and of asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA*) as new highly versatile chiral building blocks
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3. Enantioselektive Verseifungen substituierter, achiraler 3-Acyloxy-propylester mit Lipasen: Herstellung chiraler Derivate von „Tris(hydroxymethyl)methan”
4. Enzymes as selective reagents in organic synthesis: Enantioselective preparation of “asymmetrized tris (hydroxymethyl)methane”
5. Enzymes in organic synthesis: remarkable influence of a π system on the enantioselectivity in PPL catalysed monohydrolysis of 2-substituted 1,3-diacetoxypropanes.
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