Synthesis and Structure−Activity Relationships of Phenylenebis(methylene)- Linked Bis-azamacrocycles That Inhibit HIV-1 and HIV-2 Replication by Antagonism of the Chemokine Receptor CXCR4-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationships of Phenylenebis(methylene)- Linked Bis-azamacrocycles That Inhibit HIV-1 and HIV-2 Replication by Antagonism of the Chemokine Receptor CXCR4

Published:1999-08-26 Issue:19 Volume:42 Page:3971-3981
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bridger Gary J.¹,Skerlj Renato T.¹,Padmanabhan Sreenivasan¹,Martellucci Stephen A.¹,Henson Geoffrey W.¹,Struyf Sofie¹,Witvrouw Myriam¹,Schols Dominique¹,De Clercq Erik¹

Affiliation:

1. AnorMED Inc., 200-20353 64th Avenue, Langley, British Columbia V2Y 1N5, Canada, Johnson Matthey Pharmaceutical Research, 1401 King Road, West Chester, Pennsylvania 19380, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990211i

Reference21 articles.

1. Toward Improved Anti-HIV Chemotherapy: Therapeutic Strategies for Intervention with HIV Infections

2. Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

3. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

4. Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)-Linked Bis-Tetraazamacrocycles That Inhibit HIV Replication. Effects of Macrocyclic Ring Size and Substituents on the Aromatic Linker

5. Synthesis and Structure−Activity Relationships of Phenylenebis(methylene)- Linked Bis-tetraazamacrocycles That Inhibit Human Immunodeficiency Virus Replication. 2. Effect of Heteroaromatic Linkers on the Activity of Bicyclams

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