Selective synthesis of an elusive <i>C</i>-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor-Reference-Cited by-同舟云学术

Selective synthesis of an elusive C-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor

Published:2024 Issue:15 Volume:22 Page:3059-3067
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Le Roy Marie M.¹^ORCID,Claes Sandra²,Saffon-Merceron Nathalie³,Schols Dominique²^ORCID,Troadec Thibault¹^ORCID,Tripier Raphaël¹^ORCID

Affiliation:

1. Univ Brest, UMR CNRS 6521 CEMCA, 6 Avenue Victor le Gorgeu, 29200 Brest, France

2. Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium

3. Institut de Chimie de Toulouse (FR 2599), 118 route de Narbonne, 31062 Toulouse Cedex 9, France

Abstract

A rare example of C,C′-linked bis-cyclam has been synthesized with controlled manner in mild conditions thanks to the “bis-aminal” tool, and its good CXCR4-recognition properties could be demonstated in vitro.

Funder

Ligue Contre le Cancer

Région Bretagne

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D3OB02050A

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