Integrated Approach for Characterizing Bispecific Antibody/Antigens Complexes and Mapping Binding Epitopes with SEC/MALS, Native Mass Spectrometry, and Protein Footprinting-Reference-Cited by-同舟云学术

Integrated Approach for Characterizing Bispecific Antibody/Antigens Complexes and Mapping Binding Epitopes with SEC/MALS, Native Mass Spectrometry, and Protein Footprinting

Published:2020-07-08 Issue:15 Volume:92 Page:10709-10716
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Huang Richard Y.-C.¹^ORCID,Wang Feng²,Wheeler Matthew³,Wang Yun¹,Langish Robert¹,Chau Bryant²,Dong Jia²,Morishige Winse²,Bezman Natalie³,Strop Pavel²^ORCID,Rajpal Arvind²,Gudmundsson Olafur¹,Chen Guodong¹

Affiliation:

1. Pharmaceutical Candidate Optimization, Nonclinical Research and Development, Bristol Myers Squibb Company, Princeton, New Jersey 08540, United States

2. Protein Engineering, Discovery Biotherapeutics, Bristol Myers Squibb, Redwood City, California 94063, United States

3. Discovery Biology, Research and Early Development, Bristol Myers Squibb, Redwood City, California 94063, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c01876

Reference32 articles.

1. Bispecific antibodies and their applications

2. Bispecific antibodies: a mechanistic review of the pipeline

3. A systematic approach for analysis and characterization of mispairing in bispecific antibodies with asymmetric architecture