Epitope mapping of a blood–brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction
Author:
Affiliation:
1. National Research Council Canada Human Health Therapeutics Research Centre, , Ottawa, Ontario K1A 0R6, Canada
2. Department of Pharmacy, University of Copenhagen, 2100, Copenhagen, Denmark.2100
Abstract
Publisher
Oxford University Press (OUP)
Subject
Molecular Biology,Biochemistry,General Medicine
Link
https://academic.oup.com/jb/advance-article-pdf/doi/10.1093/jb/mvac088/47605392/mvac088.pdf
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3. Interactions of IGF-1 with the blood-brain barrier in vivo and in situ;Pan;Neuroendocrinology,2000
4. A novel human induced pluripotent stem cell blood–brain barrier model: applicability to study antibody-triggered receptor-mediated transcytosis;Ribecco-Lutkiewicz;Sci. Rep.,2018
5. Neurocognitive and somatic stabilization in pediatric patients with severe mucopolysaccharidosis type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial;Giugliani;Orphanet J. Rare Dis.,2018
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