Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry-Reference-Cited by-同舟云学术

Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry

Published:2016-12-08 Issue:24 Volume:88 Page:12122-12127
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Schachner Luis¹,Han Guanghui¹,Dillon Michael¹,Zhou Jianhui¹,McCarty Luke¹,Ellerman Diego¹,Yin Yiyuan¹,Spiess Christoph¹,Lill Jennie R.¹,Carter Paul J.¹,Sandoval Wendy¹

Affiliation:

1. Departments of Proteomics & Biological Resources, ‡Antibody Engineering, and §Protein Chemistry, Genentech, Inc., South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.6b02866

Reference24 articles.

1. Alternative molecular formats and therapeutic applications for bispecific antibodies

2. Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies

3. Bispecific antibodies

4. Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

5. Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry

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