Mapping the Separation Landscape in Two-Dimensional Liquid Chromatography: Blueprints for Efficient Analysis and Purification of Pharmaceuticals Enabled by Computer-Assisted Modeling-Reference-Cited by-同舟云学术

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Mapping the Separation Landscape in Two-Dimensional Liquid Chromatography: Blueprints for Efficient Analysis and Purification of Pharmaceuticals Enabled by Computer-Assisted Modeling

Published:2020-12-10 Issue:2 Volume:93 Page:964-972
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Makey Devin M.¹²,Shchurik Vladimir¹,Wang Heather¹,Lhotka Hayley R.¹³,Stoll Dwight R.²^ORCID,Vazhentsev Andrey⁴,Mangion Ian¹,Regalado Erik L.¹^ORCID,Ahmad Imad A. Haidar¹^ORCID

Affiliation:

1. Analytical Research and Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Department of Chemistry, Gustavus Adolphus College, Saint Peter, Minnesota 56082, United States

3. Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

4. Advanced Chemistry Development, Inc., Toronto, Ontario M5C 1B5, Canada

Funder

Merck

Agilent Technologies

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c03680

Reference39 articles.

1. Recent Advances in Chromatography for Pharmaceutical Analysis

2. The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug Substances

3. Structure, heterogeneity and developability assessment of therapeutic antibodies

4. Chaotropic Effects in Sub/Supercritical Fluid Chromatography via Ammonium Hydroxide in Water-Rich Modifiers: Enabling Separation of Peptides and Highly Polar Pharmaceuticals at the Preparative Scale

5. Evaluation of global conformational changes in peptides and proteins following purification by supercritical fluid chromatography

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