Identification and Quantification of Oxidation Products in Full-Length Biotherapeutic Antibodies by NMR Spectroscopy-Reference-Cited by-同舟云学术

Identification and Quantification of Oxidation Products in Full-Length Biotherapeutic Antibodies by NMR Spectroscopy

Published:2020-06-12 Issue:14 Volume:92 Page:9666-9673
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Hinterholzer Arthur¹²^ORCID,Stanojlovic Vesna²^ORCID,Regl Christof¹²,Huber Christian G.¹²^ORCID,Cabrele Chiara¹²^ORCID,Schubert Mario¹²^ORCID

Affiliation:

1. Christian Doppler Laboratory for Innovative Tools for Biosimilar Characterization, University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, Austria

2. Department of Biosciences, University of Salzburg, Billrothstrasse 11, 5020 Salzburg, Austria

Funder

Austrian Federal Ministry of Science, Research and Economy

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c00965

Reference48 articles.

1. Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

2. The oxidative environment and protein damage

3. Site-Specific Characterization and Absolute Quantification of Pegfilgrastim Oxidation by Top-Down High-Performance Liquid Chromatography–Mass Spectrometry

4. A Generic HPLC Method for Absolute Quantification of Oxidation in Monoclonal Antibodies and Fc-Fusion Proteins Using UV and MS Detection

5. Effect of Individual Fc Methionine Oxidation on FcRn Binding: Met252 Oxidation Impairs FcRn Binding More Profoundly than Met428 Oxidation

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