Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins-Reference-Cited by-同舟云学术

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Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins

Published:2023-12-20 Issue:1 Volume:23 Page:161-174
ISSN:1535-3893
Container-title:Journal of Proteome Research
language:en
Short-container-title:J. Proteome Res.

Author:

Smith Josh¹,Guapo Felipe¹,Strasser Lisa¹,Millán-Martín Silvia¹^ORCID,Milian Steven G.²,Snyder Richard O.²,Bones Jonathan¹³^ORCID

Affiliation:

1. Characterisation and Comparability Laboratory, The National Institute for Bioprocessing Research and Training, Foster Avenue, Mount Merrion, Dublin A94 X099, Ireland

2. Patheon Viral Vector Services, 13859 Progress Blvd, Alachua, Florida 32615, United States

3. School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin D04 V1W8.F, Ireland

Funder

Thermo Fisher Scientific

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.3c00513

Reference44 articles.

1. Engineering adeno-associated viruses for clinical gene therapy

2. AAV-Mediated Gene Therapy for Research and Therapeutic Purposes

3. Adeno-associated virus (AAV) vectors in cancer gene therapy

4. Characterization of Adeno-Associated Virus Capsid Proteins Using Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry

5. Viral vector platforms within the gene therapy landscape

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1. Top‐down mass spectrometry analysis of capsid proteins of recombinant adeno‐associated virus using multiple ion activations and proton transfer charge reduction;PROTEOMICS;2024-09-05

2. Advances in analytical technologies for emerging drug modalities and their separation challenges in LC-MS systems;Journal of Chromatography A;2024-09

3. A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency;International Journal of Molecular Sciences;2024-02-28

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