Process Optimization in the Synthesis of 9-[2-(Diethylphosphonomethoxy)ethyl]adenine: Replacement of Sodium Hydride with Sodium tert-Butoxide as the Base for Oxygen Alkylation-Reference-Cited by-同舟云学术

Process Optimization in the Synthesis of 9-[2-(Diethylphosphonomethoxy)ethyl]adenine: Replacement of Sodium Hydride with Sodium tert-Butoxide as the Base for Oxygen Alkylation

Published:1998-12-17 Issue:1 Volume:3 Page:53-55
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Yu Richard H.¹,Schultze Lisa M.¹,Rohloff John C.¹,Dudzinski Pawel W.¹,Kelly Daphne E.¹

Affiliation:

1. Process Research, Gilead Sciences, Inc., 353 Lakeside Drive, Foster City, California 94404, and Process Chemistry, Raylo Chemicals, Inc., 8045 Argyll Road, Edmonton, Alberta, Canada T6C4A9

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op980067v

Reference23 articles.

1. Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)

2. Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine

3. Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

4. Antiviral efficacy in mice of oral bis(POM)-PMEA, the Bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

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