An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines-Reference-Cited by-同舟云学术

An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines

Published:2020-05-29 Issue:8 Volume:24 Page:1420-1427
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Derstine Brenden P.¹,Tomlin John W.¹,Peck Cheryl L.¹,Dietz Jule-Phillip²,Herrera Brenden T.¹,Cardoso Flavio S. P.¹^ORCID,Paymode Dinesh J.¹,Yue Andrew C.¹,Arduengo Anthony J.³^ORCID,Opatz Till²^ORCID,Snead David R.¹^ORCID,Stringham Rodger W.¹,McQuade D. Tyler¹^ORCID,Gupton B. Frank¹

Affiliation:

1. Department of Chemical and Life Sciences Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, United States

2. Department of Chemistry, Johannes Gutenberg-University, Duesbergweg 10-14, 55128 Mainz, Germany

3. Department of Chemistry, The University of Alabama, Tuscaloosa, Alabama 35487, United States

Funder

Bill and Melinda Gates Foundation

Gottwald Family Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00078

Reference13 articles.

1. Antiretroviral Efficacy and Pharmacokinetics of Oral Bis(isopropyloxycarbonyloxymethyl)9-(2-Phosphonylmethoxypropyl)adenine in Mice

2. Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9- R -(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA

3. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

4. Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale

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