Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability-Reference-Cited by-同舟云学术

Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Bis(S-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

Published:1996-01-01 Issue:25 Volume:39 Page:4958-4965
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Benzaria Samira¹,Pélicano Hélène¹,Johnson Richard¹,Maury Georges¹,Imbach Jean-Louis¹,Aubertin Anne-Marie¹,Obert Georges¹,Gosselin Gilles¹

Affiliation:

1. Laboratoire de Chimie Bioorganique, case courrier 008, UMR CNRS-USTL 5625, Université Montpellier II, Sciences et Techniques du Languedoc, Place Eugène Bataillon, 34095 Montpellier Cédex 5, France, and Institut de Virologie de la Faculté de Médecine de Strasbourg, Unité INSERM 74, 3 Rue Koeberlé, 67000 Strasbourg, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960289o

Reference45 articles.

1. Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines

2. 9-(2-phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

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