A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)-Reference-Cited by-同舟云学术

A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)

Published:2000-01-21 Issue:3 Volume:43 Page:342-345
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lovell Peter J.¹,Bromidge Steven M.¹,Dabbs Steven¹,Duckworth D. Malcolm¹,Forbes Ian T.¹,Jennings Andrew J.¹,King Frank D.¹,Middlemiss Derek N.¹,Rahman Shirley K.¹,Saunders Damian V.¹,Collin Lissa L.¹,Hagan Jim J.¹,Riley Graham J.¹,Thomas David R.¹

Affiliation:

1. SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm991151j

Reference17 articles.

1. (R)-3,N-Dimethyl-N-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide: The First Selective 5-HT7 Receptor Antagonist

2. The 5-HT7 receptor: orphan found

3. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

4. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

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