Exploiting Enzyme Plasticity in Virtual Screening: High Efficiency Inhibitors of Glutamate Racemase
Author:
Affiliation:
1. Department of Biochemistry
2. Department of Microbiology
3. Institute for Genomic Biology
4. University of Illinois, Urbana, Illinois 61801
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml900005b
Reference26 articles.
1. Mechanism of the reaction catalyzed by glutamate racemase
2. Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistance
3. 4-Substituted d-Glutamic Acid Analogues: The First Potent Inhibitors of Glutamate Racemase (MurI) Enzyme with Antibacterial Activity
4. Exploitation of structural and regulatory diversity in glutamate racemases
5. Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase
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