An Atomistic Understanding of Allosteric Inhibition of Glutamate Racemase: a Dampening of Native Activation Dynamics-Reference-Cited by-同舟云学术

An Atomistic Understanding of Allosteric Inhibition of Glutamate Racemase: a Dampening of Native Activation Dynamics

Published:2020-02-17 Issue:4 Volume:15 Page:376-384
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Witkin Katie R.¹,Vance Nicholas R.¹,Caldwell Colleen²,Li Quinn²,Yu Liping²³,Spies M. Ashley¹²^ORCID

Affiliation:

1. Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutics and Experimental Therapeutics, College of PharmacyUniversity of Iowa Iowa City, Iowa 52246 USA

2. Department of Biochemistry, Carver College of MedicineUniversity of Iowa Iowa City, Iowa 52246 USA

3. NMR Core Facility, Carver College of MedicineUniversity of Iowa Iowa City, Iowa 52246 USA

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900642

Reference56 articles.

2. Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase

3. Mechanism of the reaction catalyzed by glutamate racemase

4. Purification, cloning, and cofactor independence of glutamate racemase from Lactobacillus

5. Exploiting Enzyme Plasticity in Virtual Screening: High Efficiency Inhibitors of Glutamate Racemase

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