Rapid Access to 2-Substituted Bicyclo[1.1.1]pentanes-Reference-Cited by-同舟云学术

Rapid Access to 2-Substituted Bicyclo[1.1.1]pentanes

Published:2023-01-25 Issue:5 Volume:145 Page:3092-3100
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Garry Olivia L.¹,Heilmann Michael¹,Chen Jingjia¹,Liang Yufan¹,Zhang Xiaheng¹^ORCID,Ma Xiaoshen²^ORCID,Yeung Charles S.²^ORCID,Bennett David Jonathan²^ORCID,MacMillan David W. C.¹^ORCID

Affiliation:

1. Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States

2. Department of Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts 02115, United States

Funder

Janssen Research and Development

Celgene

Princeton University

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Genentech

Pfizer

Bristol-Myers Squibb

National Institute of General Medical Sciences

Merck

Princeton Catalysis Initiative, Princeton University

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c12163

Reference34 articles.

1. Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors

2. Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

3. Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor

4. Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para -Phenyl Bioisosteres

5. Saturated bioisosteres of benzene: where to go next?

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