3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues:  High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1

Author:

Carling Robert W.1,Moore Kevin W.1,Street Leslie J.1,Wild Deborah1,Isted Catherine1,Leeson Paul D.1,Thomas Steven1,O'Connor Desmond1,McKernan Ruth M.1,Quirk Katherine1,Cook Susan M.1,Atack John R.1,Wafford Keith A.1,Thompson Sally A.1,Dawson Gerard R.1,Ferris Pushpinder1,Castro José L.1

Affiliation:

1. Departments of Medicinal Chemistry, Biochemistry, and Pharmacology, The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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