Affiliation:
1. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran
Abstract
Background:
Pyrazolophthalazinedione derivatives show various biological activities
such as anti-bacterial, anti-cancer, anti-coagulant, anti-convulsant, anti-fungal, anti-hypoglycemic,
anti-inflammatory, anti-tumor, anti-viral, cardiotonic, cytotoxic and vasorelaxant activities.
Objective:
The purpose of this study was to synthesize compounds that have various medicinal
properties.
Methods:
Diverse 3-amino-5,10-dioxo-1-phenyl-5,10-dihydro-1H-pyrazolo[1,2-b]phthal-azine-2--
carbonitriles were synthesized from the one-pot three components green synthesis of phthalhydrazides,
aromatic aldehydes and malononitrile in the presence of the proline organocatalyst in
ethanol at reflux conditions in excellent yields.
Results:
Proline was used as an efficient organocatalyst for the one-pot three components green
synthesis of diverse pyrazolophthalazinecarbonitriles. In the absence of the proline organocatalyst,
the yield was very low. Also, electron withdrawing or electron releasing groups don’t have a meaningful
effect on the reaction times and the structures of all products were in agreement with their
IR and NMR spectra.
Conclusion:
In the IR spectra, the appearance of the sharp NH2 and the CN peaks at about 3300
and 2300 cm-1, respectively confirm formation of the products.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Analytical Chemistry,Catalysis