Thermolytic Properties of 3-(2-Pyridyl)-1-propyl and 2-[N-Methyl-N-(2-pyridyl)]aminoethyl Phosphate/Thiophosphate Protecting Groups in Solid-Phase Synthesis of Oligodeoxyribonucleotides-Reference-Cited by-同舟云学术

Thermolytic Properties of 3-(2-Pyridyl)-1-propyl and 2-[N-Methyl-N-(2-pyridyl)]aminoethyl Phosphate/Thiophosphate Protecting Groups in Solid-Phase Synthesis of Oligodeoxyribonucleotides

Published:2003-12-01 Issue:26 Volume:68 Page:10123-10129
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Cieślak Jacek¹,Beaucage Serge L.¹

Affiliation:

1. Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo0354490

Reference15 articles.

1. Deoxyribonucleoside Cyclic N-Acylphosphoramidites as a New Class of Monomers for the Stereocontrolled Synthesis of Oligothymidylyl- and Oligodeoxycytidylyl- Phosphorothioates

2. The 2-(N-Formyl-N-methyl)aminoethyl Group as a Potential Phosphate/Thiophosphate Protecting Group in Solid-Phase Oligodeoxyribonucleotide Synthesis

3. The 4-oxopentyl group as a labile phosphate/thiophosphate protecting group for synthetic oligodeoxyribonucleotides

4. The 3-(N-tert-Butylcarboxamido)-1-propyl Group as an Attractive Phosphate/Thiophosphate Protecting Group for Solid-Phase Oligodeoxyribonucleotide Synthesis

5. (d) Wilk, A., Chmielewski, M. K.; Grajkowski, A.; Phillips, L. R.; Beaucage, S. L. InCurrent Protocols in Nucleic Acid Chemistry; Beaucage, S. L., Bergstrom, D. E., Glick, G. D., Jones, R. A., Eds.; John Wiley & Sons: New York, 2002; pp 3.9.1−3.9.15.

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