Synthesis of a cis 2,5-Disubstituted Morpholine by De-epimerization: Application to the Multigram Scale Synthesis of a Mineralocorticoid Antagonist-Reference-Cited by-同舟云学术

Synthesis of a cis 2,5-Disubstituted Morpholine by De-epimerization: Application to the Multigram Scale Synthesis of a Mineralocorticoid Antagonist

Published:2013-05-20 Issue:6 Volume:17 Page:934-939
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Sammons Matthew¹,Jennings Sandra M.¹,Herr Michael¹,Hulford Catherine A.¹,Wei Liuqing¹,Hallissey James F.¹,Kiser E. Jason¹,Wright Stephen W.¹,Piotrowski David W.¹

Affiliation:

1. Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op400101p

Reference24 articles.

1. Mineralocorticoid Receptor Antagonists for the Treatment of Hypertension and Diabetic Nephropathy

2. Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy

3. Synthesis and cross coupling of a highly substituted 2-pyridylboronate: application to the large scale synthesis of a mineralocorticoid antagonist

4. Wood, M. R.; Gallicchio, S. N.; Selnick, H. G.; Zartman, C. B.; Bell, I. M.; Stump, C. A.US Patent 7,629,338, Dec 8, 2009;

5. Chem. Abstr. 2007, 147, 541857.

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