Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

Author:

Koralewski Robert1,Dymek Barbara1,Mazur Marzena1,Sklepkiewicz Piotr1,Olejniczak Sylwia1,Czestkowski Wojciech1,Matyszewski Krzysztof1,Andryianau Gleb1,Niedziejko Piotr1,Kowalski Michal1,Gruza Mariusz1,Borek Bartłomiej1,Jedrzejczak Karol1,Bartoszewicz Agnieszka1,Pluta Elżbieta1,Rymaszewska Aleksandra1,Kania Magdalena1,Rejczak Tomasz1,Piasecka Sylwia1,Mlacki Michal1,Mazurkiewicz Marcin1,Piotrowicz Michał1ORCID,Salamon Magdalena1,Zagozdzon Agnieszka1,Napiorkowska-Gromadzka Agnieszka2,Bartlomiejczak Aneta2,Mozga Witold1,Dobrzański Paweł1,Dzwonek Karolina1,Golab Jakub13,Nowotny Marcin2ORCID,Olczak Jacek1ORCID,Golebiowski Adam1ORCID

Affiliation:

1. OncoArendi Therapeutics SA, Żwirki i Wigury 101, 02-089 Warsaw, Poland

2. Structural Biology Center, International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland

3. Department of Immunology, Medical University of Warsaw, Nielubowicza 5, 02-097 Warsaw, Poland

Funder

European Regional Development Fund

Narodowe Centrum Badan i Rozwoju

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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