Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors-Reference-Cited by-同舟云学术

Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors

Published:2023-03-21 Issue:4 Volume:14 Page:417-424
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Balestri Lorenzo Jacopo Ilic¹^ORCID,Trivisani Claudia Immacolata¹,Orofino Francesco¹,Fiorucci Diego¹,Truglio Giuseppina Ivana¹,D’Agostino Ilaria¹,Poggialini Federica¹^ORCID,Botta Lorenzo²³,Docquier Jean-Denis⁴⁵^ORCID,Dreassi Elena¹^ORCID

Affiliation:

1. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy

2. Lead Discovery Siena s.r.l., Via Vittorio Alfieri 31, I-53019 Castelnuovo Berardenga, Italy

3. Department of Ecological and Biological Sciences, University of Tuscia, Largo Università s.n.c., I-01100 Viterbo, Italy

4. Dipartimento di Biotecnologie Mediche, University of Siena, Viale Bracci 16, I-53100, Siena, Italy

5. Laboratoire de Bactériologie Moléculaire, Centre d’Ingénierie des Protéines, UR-InBioS, University of Liège, Allée du 6 Août, 4000 Liège, Belgium

Funder

Lead Discovery Siena Srl

Cygnet Bioscience B.V.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00472

Reference35 articles.

1. Chitin — The Undisputed Biomolecule of Great Potential

2. From bacteria to human: A journey into the world of chitinases

3. Fungal chitinases: diversity, mechanistic properties and biotechnological potential

4. Cloning of a cDNA Encoding Chitotriosidase, a Human Chitinase Produced by Macrophages

5. Identification of a Novel Acidic Mammalian Chitinase Distinct from Chitotriosidase

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