Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(R)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915)-Reference-Cited by-同舟云学术

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(R)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915)

Published:2015-02-11 Issue:4 Volume:58 Page:1669-1690
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Takahashi Hidenori,Riether Doris,Bartolozzi Alessandra,Bosanac Todd,Berger Valentina,Binetti Ralph,Broadwater John,Chen Zhidong,Crux Rebecca¹,De Lombaert Stéphane,Dave Rajvee,Dines Jonathon A.¹,Fadra-Khan Tazmeen,Flegg Adam¹,Garrigou Michael¹,Hao Ming-Hong,Huber John,Hutzler J. Matthew,Kerr Steven,Kotey Adrian¹,Liu Weimin,Lo Ho Yin,Loke Pui Leng¹,Mahaney Paige E.,Morwick Tina M.,Napier Spencer¹,Olague Alan,Pack Edward,Padyana Anil K.,Thomson David S.,Tye Heather¹,Wu Lifen,Zindell Renee M.,Abeywardane Asitha,Simpson Thomas

Affiliation:

1. Evotec, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501185j

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