Fructose-1,6-bisphosphatase Inhibitors. 2. Design, Synthesis, and Structure−Activity Relationship of a Series of Phosphonic Acid Containing Benzimidazoles that Function as 5′-Adenosinemonophosphate (AMP) Mimics-Reference-Cited by-同舟云学术

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, Synthesis, and Structure−Activity Relationship of a Series of Phosphonic Acid Containing Benzimidazoles that Function as 5′-Adenosinemonophosphate (AMP) Mimics

Published:2009-11-30 Issue:1 Volume:53 Page:441-451
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dang Qun¹,Kasibhatla Srinivas Rao¹,Xiao Wei¹,Liu Yan¹,DaRe Jay¹,Taplin Frank¹,Reddy K. Raja¹,Scarlato Gerard R.¹,Gibson Tony¹,van Poelje Paul D.¹,Potter Scott C.¹,Erion Mark D.¹

Affiliation:

1. Departments of Medicinal Chemistry and Biochemistry, Metabasis Therapeutics, Inc., 11119 North Torrey Pines Road, La Jolla, California 92037

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901420x

Reference26 articles.

1. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes

2. Advances in pleural disease

3. Structure-Guided Design of AMP Mimics That Inhibit Fructose-1,6-bisphosphatase with High Affinity and Specificity