Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes-Reference-Cited by-同舟云学术

Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes

Published:2008-09-13 Issue:10 Volume:21 Page:2035-2041
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Madsen Kim G.¹,Grönberg Gunnar¹,Skonberg Christian¹,Jurva Ulrik¹,Hansen Steen H.¹,Olsen Jørgen¹

Affiliation:

1. Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark, Medicinal Chemistry and DMPK & Physical Chemistry, Lead Generation, AstraZeneca R&D, Mölndal, Sweden, and ADME & Assay Technology, Novo Nordisk A/S, DK-2760 Måløv, Denmark

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx8002214

Reference25 articles.

1. Mechanisms of Troglitazone Hepatotoxicity

2. Studies on the Metabolism of Troglitazone to Reactive Intermediates in Vitro and in Vivo. Evidence for Novel Biotransformation Pathways Involving Quinone Methide Formation and Thiazolidinedione Ring Scission

3. Enzyme-Induction Dependent Bioactivation of Troglitazone and Troglitazone Quinone In Vivo

4. METABOLIC ACTIVATION OF TROGLITAZONE: IDENTIFICATION OF A REACTIVE METABOLITE AND MECHANISMS INVOLVED

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