Enzyme-Induction Dependent Bioactivation of Troglitazone and Troglitazone Quinone In Vivo
Author:
Affiliation:
1. Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool L69 3GE, U.K., and GlaxoWellcome Research and Development, Greenford, Middlesex UB6 0HE, U.K.
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx0001981
Reference40 articles.
1. Troglitazone
2. Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration
3. Troglitazone and Liver Function Abnormalities
4. Two Cases of Severe Clinical and Histologic Hepatotoxicity Associated with Troglitazone
5. Troglitazone-Induced Hepatic Failure Leading to Liver Transplantation: A Case Report
Cited by 98 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Development of a Novel In Silico Classification Model to Assess Reactive Metabolite Formation in the Cysteine Trapping Assay and Investigation of Important Substructures;Biomolecules;2024-04-30
2. Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes;Archives of Toxicology;2024-03-23
3. Development of a novelin silicoclassification model to assess reactive metabolite formation in the cysteine trapping assay and investigation of important substructures;2024-02-14
4. Microphysiological Models for Mechanistic-Based Prediction of Idiosyncratic DILI;Cells;2023-05-25
5. Chemical Structural Alert and Reactive Metabolite Concept as Applied in Medicinal Chemistry to Minimize the Toxicity of Drug Candidates;Drug Metabolism Handbook;2022-11-18
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3