Identification of a Crucial Amino Acid in the Helix Position 6.51 of Human Tachykinin Neurokinin 1 and 3 Receptors Contributing to the Insurmountable Mode of Antagonism by Dual NK1/NK3 Antagonists-Reference-Cited by-同舟云学术

Identification of a Crucial Amino Acid in the Helix Position 6.51 of Human Tachykinin Neurokinin 1 and 3 Receptors Contributing to the Insurmountable Mode of Antagonism by Dual NK1/NK3 Antagonists

Published:2012-05-22 Issue:11 Volume:55 Page:5061-5076
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bissantz Caterina¹,Bohnert Claudia¹,Hoffmann Torsten¹,Marcuz Anne¹,Schnider Patrick¹,Malherbe Pari¹

Affiliation:

1. Medicinal Chemistry and ‡DTA CNS, pRED, Pharma Research and Early Development, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, CH4070, Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2017072

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4. Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3 Receptor. 2. Identification of (S)-N-(1-Phenylpropyl)-3-hydroxy-2- phenylquinoline-4-carboxamide (SB 223412)

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