Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium-Reference-Cited by-同舟云学术

Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium

Published:2020-01-07 Issue:1 Volume:33 Page:7-9
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Ferreira Sofia¹,Fisher Ciarán¹,Furlong Laura I.²,Laplanche Loic³^ORCID,Park Brian Kevin⁴,Pin Carmen⁵,Saez-Rodriguez Julio⁶,Trairatphisan Panuwat³⁶

Affiliation:

1. Certara UK Limited, Simcyp Division, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, United Kingdom

2. Research Programme on Biomedical Informatics (GRIB), IMIM (Hospital del Mar Medical Research Institute), Pompeu Fabra University (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain

3. Drug Metabolism Pharmacokinetics and Bioanalysis, AbbVie Deutschland GmbH & Co. KG, D-67008 Ludwigshafen, Germany

4. MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, United Kingdom

5. Clinical Pharmacology, ADME, and AI, Clinical Pharmacology and Safety Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge CB2 0SL, United Kingdom

6. Faculty of Medicine, Institute of Computational Biomedicine, Heidelberg University, 69120 Heidelberg, Germany

Funder

IMI2 Call6

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.9b00499

Reference5 articles.

1. Multiscale Mathematical Model of Drug-Induced Proximal Tubule Injury: Linking Urinary Biomarkers to Epithelial Cell Injury and Renal Dysfunction

2. Better prediction of the local concentration–effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development