ELIXIR and Toxicology: a community in development

Author:

Martens MarvinORCID,Stierum Rob,Schymanski Emma L.ORCID,Evelo Chris T.ORCID,Aalizadeh Reza,Aladjov Hristo,Arturi KasiaORCID,Audouze Karine,Babica Pavel,Berka Karel,Bessems JosORCID,Blaha Ludek,Bolton Evan E.ORCID,Cases Montserrat,Damalas Dimitrios Ε.ORCID,Dave Kirtan,Dilger MarcoORCID,Exner Thomas,Geerke Daan P.,Grafström Roland,Gray Alasdair,Hancock John M.,Hollert Henner,Jeliazkova Nina,Jennen DanyelORCID,Jourdan FabienORCID,Kahlem Pascal,Klanova Jana,Kleinjans Jos,Kondic Todor,Kone Boï,Lynch IseultORCID,Maran Uko,Martinez Cuesta SergioORCID,Ménager Hervé,Neumann SteffenORCID,Nymark PennyORCID,Oberacher Herbert,Ramirez Noelia,Remy SylvieORCID,Rocca-Serra Philippe,Salek Reza M.ORCID,Sallach Brett,Sansone Susanna-Assunta,Sanz FerranORCID,Sarimveis Haralambos,Sarntivijai SiraratORCID,Schulze TobiasORCID,Slobodnik Jaroslav,Spjuth OlaORCID,Tedds Jonathan,Thomaidis NikolaosORCID,Weber Ralf J.M.,van Westen Gerard J.P.ORCID,Wheelock Craig E.ORCID,Williams Antony J.ORCID,Witters HildaORCID,Zdrazil BarbaraORCID,Županič AnžeORCID,Willighagen Egon L.ORCID

Abstract

Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology, and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the linkage of various life science efforts around modern predictive toxicology, the establishment of a new ELIXIR Community is seen as instrumental. In the past few years, joint efforts, building on incidental overlap, have been piloted in the context of ELIXIR. For example, the EU-ToxRisk, diXa, HeCaToS, transQST, and the nanotoxicology community have worked with the ELIXIR TeSS, Bioschemas, and Compute Platforms and activities. In 2018, a core group of interested parties wrote a proposal, outlining a sketch of what this new ELIXIR Toxicology Community would look like. A recent workshop (held September 30th to October 1st, 2020) extended this into an ELIXIR Toxicology roadmap and a shortlist of limited investment-high gain collaborations to give body to this new community. This Whitepaper outlines the results of these efforts and defines our vision of the ELIXIR Toxicology Community and how it complements other ELIXIR activities.

Funder

Umweltbundesamt

Wellcome Trust

H2020 Marie Skłodowska-Curie Actions

Agence Nationale de la Recherche

Bundesministerium für Bildung und Forschung

Horizon 2020

Eesti Teadusagentuur

European Regional Development Fund

Stiftelsen Forska Utan Djurförsök

LIFE programme

Miguel Servet

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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